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CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME
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DeCS
Descriptor
English
:
Cholesterol Side-Chain Cleavage Enzyme
Descriptor
Spanish
:
Enzima de Desdoblamiento de la Cadena Lateral del Colesterol
Descriptor
Portuguese
:
Enzima de Clivagem da Cadeia Lateral do Colesterol
Synonyms
English
:
CYP11A1
Cholesterol Desmolase
Cholesterol Monooxygenase (Side-Chain-Cleaving)
Cytochrome P-450 CYP11A1
Cytochrome P-450(scc)
Tree Number:
D08.244.453.915.212
D08.811.682.690.708.170.915.212
D08.811.682.690.708.783.212
D12.776.422.220.453.915.212
Definition
English
:
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27
cholesterol
to C21
pregnenolone
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid
hormones.
History Note
English
:
2003 (1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23192
Unique Identifier:
D002786
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS